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In 1511 the Portuguese were the first Europeans to reach the city of Guangzhou by the sea and they settled on its port for a commercial monopoly of trade with other nations They were later expelled from their settlements but they were allowed the use of Macau which was also occupied in 1511 and to be appointed in 1557 as the base for doing business with Guangzhou the quasi-monopoly on foreign trade in the region would be maintained by the Portuguese until the early seventeenth century when the Spanish and Dutch arrived. .

Some of the academic and research health institutions at the center include MD Anderson Cancer Center Baylor College of Medicine UT Health Science Center Memorial Hermann Hospital Houston Methodist Hospital Texas Children's Hospital and University of Houston College of Pharmacy. Battle of Europe air operations Other More than 235 establishments in the Houston metro area manufacture plastic and rubber products. Houston dominates the U.S production of three major resins: polyethylene (38.7% of U.S capacity); polyvinyl chloride (35.9% of U.S capacity) and polypropylene (48.4% of U.S capacity). Though Houston is the largest city in the United States without formal zoning regulations it has developed similarly to other Sun Belt cities because the city's land use regulations and legal covenants have played a similar role. Regulations include mandatory lot size for single-family houses and requirements that parking be available to tenants and customers Such restrictions have had mixed results Though some have blamed the city's low density urban sprawl and lack of pedestrian-friendliness on these policies the city's land use has also been credited with having significant affordable housing sparing Houston the worst effects of the 2008 real estate crisis the city issued 42,697 building permits in 2008 and was ranked first in the list of healthiest housing markets for 2009, (11.9) 46.2 2 Surface water 17 Joan Huffman Republican 2008 Meyerland Bellaire West University Place much of Greater Katy area far west Houston Barker Reservoir. 7.2 Pop The Niels and Mellie Esperson buildings are examples of Italian Renaissance architecture in downtown Houston. Designed by John Eberson the two buildings were built in 1927 and 1941 respectively. They are detailed with massive columns great urns terraces and a grand tempietto at the top similar to one built in the courtyard of San Pietro in Rome in 1502. Mellie Esperson had the first building constructed for her husband Niels a real estate and oil tycoon. His name is carved on the side of the building in large letters at street level the name "Mellie Esperson" is carved on the accompanying structure known as the Mellie Esperson building although it is really just a 19-story annex to the original building, See also: List of mammals of Texas List of birds of Texas List of reptiles of Texas and List of amphibians of Texas.