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The region also contains Sam Houston State University in Huntsville and Stephen F Austin State University in Nacogdoches which help contribute millions of dollars into the Deep East Texas economy Texas A&M University-Texarkana University of Texas at Tyler LeTourneau University and East Texas Baptist University are a few of the smaller universities in East Texas Texas A&M University-Commerce is right outside East Texas and is formerly known as East Texas State University while A&M-Texarkana was a branch campus of ETSU, As a seafaring people in the south-westernmost region of Europe the Portuguese became natural leaders of exploration during the Middle Ages Faced with the options of either accessing other European markets by sea by exploiting its seafaring prowess or by land and facing the task of crossing Castile and Aragon territory it is not surprising that goods were sent via the sea to England Flanders Italy and the Hanseatic league towns.[citation needed]. Main articles: Genocide the Holocaust Nazi concentration camps Extermination camp Forced labour under German rule during World War II Kidnapping of children by Nazi Germany and Nazi human experimentation! .

. The following year the War of the Quadruple Alliance pitted Spain against France which immediately moved to take over Spanish interests in North America in June 1719 seven Frenchmen from Natchitoches took control of the mission San Miguel de los Adaes from its sole defender who did not know that the countries were at war the French soldiers explained that 100 additional soldiers were coming and the Spanish colonists missionaries and remaining soldiers fled to San Antonio, Portuguese North America (in present-day Canada); Vaz Dourado c.1576.